Targeting Neph1 and ZO-1 protein-protein interaction in podocytes prevents podocyte injury and preserves glomerular filtration function

Targeting protein-protein interaction (PPI) is rapidly becoming an attractive alternative for drug development. While drug development commonly involves inhibiting a PPI, in this study, we show that stabilizing PPI may also be therapeutically beneficial. Junctional proteins Neph1 and ZO-1 and their...

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Pubblicato in:Sci Rep
Autori principali: Sagar, Amin, Arif, Ehtesham, Solanki, Ashish Kumar, Srivastava, Pankaj, Janech, Michael G., Kim, Seok-Hyung, Lipschutz, Joshua H., Kwon, Sang-Ho, Ashish, Nihalani, Deepak
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608913/
https://ncbi.nlm.nih.gov/pubmed/28935902
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12134-8
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