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Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gα(i1)
Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transduction pathways, which is a well-known target for drug development. AC is regulated by activated stimulatory (Gα(s)) and inhibitory (Gα(i)) G proteins in the cytosol. Although experimental studies hav...
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| Publicat a: | PLoS Comput Biol |
|---|---|
| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5608429/ https://ncbi.nlm.nih.gov/pubmed/28892485 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005673 |
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