Regulation of adenylyl cyclase 5 in striatal neurons confers the ability to detect coincident neuromodulatory signals

Long-term potentiation and depression of synaptic activity in response to stimuli is a key factor in reinforcement learning. Strengthening of the corticostriatal synapses depends on the second messenger cAMP, whose synthesis is catalysed by the enzyme adenylyl cyclase 5 (AC5), which is itself regula...

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Udgivet i:PLoS Comput Biol
Main Authors: Bruce, Neil J., Narzi, Daniele, Trpevski, Daniel, van Keulen, Siri C., Nair, Anu G., Röthlisberger, Ursula, Wade, Rebecca C., Carloni, Paolo, Hellgren Kotaleski, Jeanette
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6821081/
https://ncbi.nlm.nih.gov/pubmed/31665146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1007382
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