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A bifunctional Gα(i)/Gα(s) modulatory peptide that attenuates adenylyl cyclase activity

Signaling via G-protein coupled receptors is initiated by receptor-catalyzed nucleotide exchange on Gα subunits normally bound to GDP and Gβγ. Activated Gα·GTP then regulates effectors such as adenylyl cyclase. Except for Gβγ, no known regulators bind the adenylyl cyclase-stimulatory subunit Gα(s) i...

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Main Authors: Johnston, Christopher A., Ramer, J. Kevin, Blaesius, Rainer, Fredericks, Zoey, Watts, Val J., Siderovski, David P.
Formato: Artigo
Idioma:Inglês
Publicado: 2005
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1363735/
https://ncbi.nlm.nih.gov/pubmed/16225870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2005.09.059
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