Minimal determinants for binding activated G-alpha from the structure of a G-alpha-i1/peptide dimer

G-proteins cycle between an inactive GDP-bound state and active GTP-bound state, serving as molecular switches that coordinate cellular signaling. We recently used phage-display to identify a series of peptides that bind Gα subunits in a nucleotide-dependent manner [Johnston, C. A., Willard, F. S.,...

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Hauptverfasser: Johnston, Christopher A., Lobanova, Ekaterina S., Shavkunov, Alexander S., Low, Justin, Ramer, J. Kevin, Blaesius, Rainer, Fredericks, Zoey, Willard, Francis S., Kuhlman, Brian, Arshavsky, Vadim Y., Siderovski, David P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2597383/
https://ncbi.nlm.nih.gov/pubmed/16981699
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi0613832
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