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Exploring the inhibition mechanism of adenylyl cyclase type 5 by n-terminal myristoylated Gα(i1)

Adenylyl cyclase (AC) is an important messenger involved in G-protein-coupled-receptor signal transduction pathways, which is a well-known target for drug development. AC is regulated by activated stimulatory (Gα(s)) and inhibitory (Gα(i)) G proteins in the cytosol. Although experimental studies hav...

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Bibliografiske detaljer
Udgivet i:PLoS Comput Biol
Main Authors: van Keulen, Siri Camee, Rothlisberger, Ursula
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5608429/
https://ncbi.nlm.nih.gov/pubmed/28892485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005673
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