Tracking progressive pathological and functional decline in the rTg4510 mouse model of tauopathy

BACKGROUND: The choice and appropriate use of animal models in drug discovery for Alzheimer’s disease (AD) is pivotal to successful clinical translation of novel therapeutics, yet true alignment of research is challenging. Current models do not fully recapitulate the human disease, and even exhibit...

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Vydáno v:Alzheimers Res Ther
Hlavní autoři: Blackmore, Thomas, Meftah, Soraya, Murray, Tracey Karen, Craig, Peter James, Blockeel, Anthony, Phillips, Keith, Eastwood, Brian, O’Neill, Michael J., Marston, Hugh, Ahmed, Zeshan, Gilmour, Gary, Gastambide, Francois
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607580/
https://ncbi.nlm.nih.gov/pubmed/28931441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13195-017-0306-2
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