Conditional Deletion of Prnp Rescues Behavioral and Synaptic Deficits after Disease Onset in Transgenic Alzheimer's Disease

Biochemical and genetic evidence implicate soluble oligomeric amyloid-β (Aβo) in triggering Alzheimer's disease (AD) pathophysiology. Moreover, constitutive deletion of the Aβo-binding cellular prion protein (PrP(C)) prevents development of memory deficits in APP(swe)/PS1ΔE9 mice, a model of fa...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Salazar, Santiago V., Gallardo, Christopher, Kaufman, Adam C., Herber, Charlotte S., Haas, Laura T., Robinson, Sophie, Manson, Jean C., Lee, Michael K., Strittmatter, Stephen M.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607466/
https://ncbi.nlm.nih.gov/pubmed/28842420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0722-17.2017
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