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Identification and characterization of a novel Sso7d scaffold-based binder against Notch1

Notch signaling has important functions in regulating cell growth and development, misregulation of which has been implicated in various cancers. Monoclonal antibodies (mAbs) targeting Notch protein activity have already moved into clinical trials. However due to the limitations associated with cost...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Gocha, Tenzin, Rao, Balaji M., DasGupta, Ramanuj
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607287/
https://ncbi.nlm.nih.gov/pubmed/28931897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12246-1
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