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Design of pH Sensitive Binding Proteins from the Hyperthermophilic Sso7d Scaffold
We have engineered pH sensitive binding proteins for the Fc portion of human immunoglobulin G (hIgG) (hFc) using two different strategies – histidine scanning and random mutagenesis. We obtained an hFc-binding protein, Sso7d-hFc, through mutagenesis of the Sso7d protein from the hyperthermophilic ar...
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| Autors principals: | , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Public Library of Science
2012
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3492137/ https://ncbi.nlm.nih.gov/pubmed/23145025 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048928 |
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