IDENTIFICATION AND CHARACTERIZATION OF NOVEL SIRTUIN INHIBITOR SCAFFOLDS

The sirtuin proteins are broadly conserved NAD(+)-dependant deacetylases that are implicated in diverse biological processes including DNA recombination and repair, transcriptional silencing, longevity, apoptosis, axonal protection, insulin signaling and fat mobilization. Because of these associatio...

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Detalhes bibliográficos
Main Authors: Sanders, Brandi D., Jackson, Brittany, Brent, Michael, Taylor, Alexander M., Schreiber, Stuart L., Howitz, Konrad, Marmorstein, Ronen
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2929362/
https://ncbi.nlm.nih.gov/pubmed/19734050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.07.073
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