Molecular docking-aided identification of small molecule inhibitors targeting β-catenin-TCF4 interaction

Here we report a molecular docking-based approach to identify small molecules that can target the β-catenin (β-cat)-TCF4 protein-protein interaction (PPI), a key effector complex for nuclear Wnt signaling activity. Specifically, we developed and optimized a computational model of β-cat using publicl...

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Publicat a:iScience
Autors principals: Low, Joo-Leng, Du, Weina, Gocha, Tenzin, Oguz, Gokce, Zhang, Xiaoqian, Chen, Ming Wei, Masirevic, Srdan, Yim, Daniel Guo Rong, Tan, Iain Bee Huat, Ramasamy, Adaikalavan, Fan, Hao, DasGupta, Ramanuj
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2021
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8184503/
https://ncbi.nlm.nih.gov/pubmed/34142050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2021.102544
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