4-Aroyl-3-hydroxy-5-phenyl-1H-pyrrol-2(5H)-ones as N-Formyl Peptide Receptor 1 (FPR1) Antagonists

Formyl peptide receptors (FPRs) are expressed on a variety of leukocytes and play important roles in inflammation. Thus, FPR antagonists may represent novel therapeutics for modulating innate immunity and treating inflammatory diseases. Previously, 1H-pyrrol-2(5H)-ones were reported to be potent and...

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Publicado no:Biochem Pharmacol
Main Authors: Kirpotina, Liliya N., Schepetkin, Igor A., Khlebnikov, Andrei I., Ruban, Olga I., Ge, Yunjun, Ye, Richard D., Kominsky, Douglas J., Quinn, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607094/
https://ncbi.nlm.nih.gov/pubmed/28690139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bcp.2017.07.004
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