Epidermal growth factor receptor mediated proliferation depends on increased Lipid Droplet density regulated via a negative regulatory loop with FOXO3/Sirtuin6

The proliferation of colon cancer cells is mediated in part by epidermal growth factor receptor (EGFR) signaling and requires sustained levels of cellular energy to meet its high metabolic needs. Intracellular lipid droplets (LDs) are a source of energy used for various cellular functions and they a...

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Detalhes bibliográficos
Publicado no:Biochem Biophys Res Commun
Main Authors: Penrose, Harrison, Heller, Sandra, Cable, Chloe, Makboul, Rania, Chadalawada, Gita, Chen, Ying, Crawford, Susan E., Savkovic, Suzana D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607009/
https://ncbi.nlm.nih.gov/pubmed/26657850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2015.11.119
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