FOXO3 Growth Inhibition of Colonic Cells Is Dependent on Intraepithelial Lipid Droplet Density

Forkhead transcription factor FOXO3 plays a critical role in suppressing tumor growth, in part, by increasing the cell cycle inhibitor p27kip1, and Foxo3 deficiency in mice results in marked colonic epithelial proliferation. Here, we show in Foxo3-deficient colonic epithelial cells a striking increa...

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Detalhes bibliográficos
Main Authors: Qi, Wentao, Fitchev, Philip S., Cornwell, Mona L., Greenberg, Jordan, Cabe, Maleen, Weber, Christopher R., Roy, Hemant K., Crawford, Susan E., Savkovic, Suzana D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Lipids
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3675566/
https://ncbi.nlm.nih.gov/pubmed/23603907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.470617
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