The non-canonical poly(A) polymerase FAM46C acts as an onco-suppressor in multiple myeloma

FAM46C is one of the most frequently mutated genes in multiple myeloma. Here, using a combination of in vitro and in vivo approaches, we demonstrate that FAM46C encodes an active non-canonical poly(A) polymerase which enhances mRNA stability and gene expression. Reintroduction of active FAM46C into...

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Udgivet i:Nat Commun
Main Authors: Mroczek, Seweryn, Chlebowska, Justyna, Kuliński, Tomasz M., Gewartowska, Olga, Gruchota, Jakub, Cysewski, Dominik, Liudkovska, Vladyslava, Borsuk, Ewa, Nowis, Dominika, Dziembowski, Andrzej
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606997/
https://ncbi.nlm.nih.gov/pubmed/28931820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00578-5
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