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Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Islet amyloid is present in more than 90% of individuals with type 2 diabetes, where it contributes to β-cell apoptosis and insufficient insulin secretion. Apoptosis repressor with caspase recruitment domain (ARC) binds and inactivates components of the intrinsic and extrinsic apoptosis pathways and...

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Bibliographische Detailangaben
Veröffentlicht in:	Diabetes
Hauptverfasser:	Templin, Andrew T., Samarasekera, Tanya, Meier, Daniel T., Hogan, Meghan F., Mellati, Mahnaz, Crow, Michael T., Kitsis, Richard N., Zraika, Sakeneh, Hull, Rebecca L., Kahn, Steven E.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Diabetes Association 2017
Schlagworte:	Islet Studies
Online Zugang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC5606321/ https://ncbi.nlm.nih.gov/pubmed/28729244 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1352
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Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

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