Apoptosis Repressor With Caspase Recruitment Domain Ameliorates Amyloid-Induced β-Cell Apoptosis and JNK Pathway Activation

Islet amyloid is present in more than 90% of individuals with type 2 diabetes, where it contributes to β-cell apoptosis and insufficient insulin secretion. Apoptosis repressor with caspase recruitment domain (ARC) binds and inactivates components of the intrinsic and extrinsic apoptosis pathways and...

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Vydáno v:Diabetes
Hlavní autoři: Templin, Andrew T., Samarasekera, Tanya, Meier, Daniel T., Hogan, Meghan F., Mellati, Mahnaz, Crow, Michael T., Kitsis, Richard N., Zraika, Sakeneh, Hull, Rebecca L., Kahn, Steven E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Diabetes Association 2017
Témata:
Islet Studies
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606321/
https://ncbi.nlm.nih.gov/pubmed/28729244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1352
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