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Non-internalizing antibody-drug conjugates display potent anti-cancer activity upon proteolytic release of monomethyl auristatin E in the sub-endothelial extracellular matrix

Antibody-drug conjugates (ADCs) represent a promising class of biopharmaceuticals with the potential to localize at the tumor site and improve the therapeutic index of cytotoxic drugs. While it is generally believed that ADCs need to be internalized into tumor cells in order to display optimal thera...

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Detalhes bibliográficos
Publicado no:Int J Cancer
Main Authors: Gébleux, Rémy, Stringhini, Marco, Casanova, Ruben, Soltermann, Alex, Neri, Dario
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606289/
https://ncbi.nlm.nih.gov/pubmed/27943268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.30569
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