Activating Autophagy Enhanced the Antitumor Effect of Antibody Drug Conjugates Rituximab-Monomethyl Auristatin E

BACKGROUND: Antibody drug conjugate (ADC) showed potent therapeutic efficacy in several types of cancers. The role of autophagy in antitumor effects of ADC remains unclear. METHODS: In this study, the ADC, Rituximab-monomethyl auristatin E (MMAE) with a Valine–Citrulline cleavable linker, was design...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Immunol
Auteurs principaux: Wang, Yichen, Zhang, Xuyao, Fan, Jiajun, Chen, Wei, Luan, Jingyun, Nan, Yanyang, Wang, Shaofei, Chen, Qicheng, Zhang, Yujie, Wu, Youling, Ju, Dianwen
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2018
Sujets:
Immunology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6085421/
https://ncbi.nlm.nih.gov/pubmed/30123222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2018.01799
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