Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry

Prolonged exposure to thiopurines (eg, mercaptopurine [MP]) is essential for curative therapy in acute lymphoblastic leukemia (ALL), but is also associated with frequent dose-limiting hematopoietic toxicities, which is partly explained by inherited genetic polymorphisms in drug metabolizing enzymes...

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Veröffentlicht in:Blood
Hauptverfasser: Moriyama, Takaya, Yang, Yung-Li, Nishii, Rina, Ariffin, Hany, Liu, Chengcheng, Lin, Ting-Nien, Yang, Wenjian, Lin, Dong-Tsamn, Yu, Chih-Hsiang, Kham, Shirley, Pui, Ching-Hon, Evans, William E., Jeha, Sima, Relling, Mary V., Yeoh, Allen Eng-Juh, Yang, Jun J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2017
Schlagworte:
Lymphoid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606007/
https://ncbi.nlm.nih.gov/pubmed/28659275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-05-782383
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