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Impact of NUDT15 genetics on severe thiopurine-related hematotoxicity in patients with European ancestry
PURPOSE: Severe hematotoxicity in patients with thiopurine therapy has been associated with genetic polymorphisms in the thiopurine S-methyltransferase (TPMT). While TPMT genetic testing is clinically implemented for dose individualization, alterations in the nudix hydrolase 15 (NUDT15) emerged as i...
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| Опубликовано в: : | Genet Med |
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| Главные авторы: | , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Nature Publishing Group US
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6752748/ https://ncbi.nlm.nih.gov/pubmed/30728528 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-019-0448-7 |
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