A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

Understanding and blocking the self-renewal pathway of preleukemia stem cells could prevent acute myeloid leukemia (AML) relapse. In this study, we show that increased FOXO1 represents a critical mechanism driving aberrant self-renewal in preleukemic cells expressing the t(8;21)-associated oncogene...

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Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Lin, Shan, Ptasinska, Anetta, Chen, Xiaoting, Shrestha, Mahesh, Assi, Salam A., Chin, Paulynn S., Imperato, Maria R., Aronow, B. J., Zhang, Jingsong, Weirauch, Matthew T., Bonifer, Constanze, Mulloy, James C.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2017
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5606002/
https://ncbi.nlm.nih.gov/pubmed/28710059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-11-750976
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