Influenza Virus Hemagglutinin Stalk-Specific Antibodies in Human Serum are a Surrogate Marker for In Vivo Protection in a Serum Transfer Mouse Challenge Model

The immunogenicity of current influenza virus vaccines is assessed by measuring an increase of influenza virus-specific antibodies in a hemagglutination inhibition assay. This method exclusively measures antibodies against the hemagglutinin head domain. While this domain is immunodominant, it has be...

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Publicado no:mBio
Main Authors: Jacobsen, Henning, Rajendran, Madhusudan, Choi, Angela, Sjursen, Haakon, Brokstad, Karl A., Cox, Rebecca J., Palese, Peter, Krammer, Florian, Nachbagauer, Raffael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605943/
https://ncbi.nlm.nih.gov/pubmed/28928215
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.01463-17
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