LMO1 Synergizes with MYCN to Promote Neuroblastoma Initiation and Metastasis

A genome-wide association study identified LMO1, which encodes a LIM-domain-only transcriptional cofactor, as a neuroblastoma susceptibility gene that functions as an oncogene in high-risk neuroblastoma. Here we show that dβh promoter-mediated expression of LMO1 in zebrafish synergizes with MYCN to...

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Publicado no:Cancer Cell
Main Authors: Zhu, Shizhen, Zhang, Xiaoling, Weichert-Leahey, Nina, Dong, Zhiwei, Zhang, Cheng, Lopez, Gonzalo, Tao, Ting, He, Shuning, Wood, Andrew C., Oldridge, Derek, Ung, Choong Yong, van Ree, Janine H., Khan, Amish, Salazar, Brittany M., da Rocha, Edroaldo Lummertz, Zimmerman, Mark W., Guo, Feng, Cao, Hong, Hou, Xiaonan, Weroha, S. John, Perez-Atayde, Antonio R., Neuberg, Donna S., Meves, Alexander, McNiven, Mark A., van Deursen, Jan M., Li, Hu, Maris, John M., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605802/
https://ncbi.nlm.nih.gov/pubmed/28867147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.08.002
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