ASCL1 is a MYCN- and LMO1-dependent member of the adrenergic neuroblastoma core regulatory circuitry

A heritable polymorphism within regulatory sequences of the LMO1 gene is associated with its elevated expression and increased susceptibility to develop neuroblastoma, but the oncogenic pathways downstream of the LMO1 transcriptional co-regulatory protein are unknown. Our ChIP-seq and RNA-seq analys...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Wang, Lu, Tan, Tze King, Durbin, Adam D., Zimmerman, Mark W., Abraham, Brian J., Tan, Shi Hao, Ngoc, Phuong Cao Thi, Weichert-Leahey, Nina, Akahane, Koshi, Lawton, Lee N., Rokita, Jo Lynne, Maris, John M., Young, Richard A., Look, A. Thomas, Sanda, Takaomi
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2019
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901540/
https://ncbi.nlm.nih.gov/pubmed/31819055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13515-5
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