Critical Role for GAB2 in Neuroblastoma Pathogenesis Through the Promotion of SHP2/MYCN Cooperation

Growing evidence suggests a major role for Src homology-2 domain-containing phosphatase 2 (SHP2/PTPN11) in MYCN-driven high-risk neuroblastoma, although biologic confirmation and a plausible mechanism for this contribution are lacking. Using a zebrafish model of MYCN-overexpressing neuroblastoma, we...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Zhang, Xiaoling, Dong, Zhiwei, Zhang, Cheng, Ung, Choong Yong, He, Shuning, Tao, Ting, Oliveira, Andre M., Meves, Alexander, Ji, Baoan, Look, A. Thomas, Li, Hu, Neel, Benjamin G., Zhu, Shizhen
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5393048/
https://ncbi.nlm.nih.gov/pubmed/28329685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.02.065
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