ADAM10-mediated ICOSL Shedding on B cells is Necessary for Proper T cell ICOS Regulation and T(FH) Responses

The proper regulation of inducible costimulator (ICOS) and its ligand (ICOSL) have been shown to be essential for maintaining proper immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant antibody production resembling lupus....

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Lownik, Joseph C, Luker, Andrea J., Damle, Sheela R., Cooley, Lauren Folgosa, El Sayed, Riham, Hutloff, Andreas, Pitzalis, Costantino, Martin, Rebecca K., El Shikh, Mohey Eldin M, Conrad, Daniel H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605448/
https://ncbi.nlm.nih.gov/pubmed/28814605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700833
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