ADAM10-mediated ICOSL Shedding on B cells is Necessary for Proper T cell ICOS Regulation and T(FH) Responses

The proper regulation of inducible costimulator (ICOS) and its ligand (ICOSL) have been shown to be essential for maintaining proper immune homeostasis. Loss of either protein results in defective humoral immunity, and overexpression of ICOS results in aberrant antibody production resembling lupus....

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Библиографические подробности
Опубликовано в: :J Immunol
Главные авторы: Lownik, Joseph C, Luker, Andrea J., Damle, Sheela R., Cooley, Lauren Folgosa, El Sayed, Riham, Hutloff, Andreas, Pitzalis, Costantino, Martin, Rebecca K., El Shikh, Mohey Eldin M, Conrad, Daniel H.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605448/
https://ncbi.nlm.nih.gov/pubmed/28814605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700833
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