Vaccines Targeting PreS1 Domain Overcome Immune Tolerance in HBV Carrier Mice

Strong tolerance to HBV surface antigens limits the therapeutic effect of the conventional HBsAg vaccination in both preclinical animal models and patients with chronic hepatitis B (CHB) infection. In contrast, we observed that clinical CHB patients presented less immune tolerance to the preS1 domai...

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Dades bibliogràfiques
Publicat a:Hepatology
Autors principals: Bian, Yingjie, Zhang, Zheng, Sun, Zhichen, Zhao, Juanjuan, Zhu, Danming, Wang, Yang, Fu, Sherry, Guo, Jingya, Liu, Longchao, Su, Lishan, Wang, Fu-sheng, Fu, Yang-Xin, Peng, Hua
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605403/
https://ncbi.nlm.nih.gov/pubmed/28445927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29239
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