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Vaccines Targeting PreS1 Domain Overcome Immune Tolerance in HBV Carrier Mice
Strong tolerance to HBV surface antigens limits the therapeutic effect of the conventional HBsAg vaccination in both preclinical animal models and patients with chronic hepatitis B (CHB) infection. In contrast, we observed that clinical CHB patients presented less immune tolerance to the preS1 domai...
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| Publicado no: | Hepatology |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5605403/ https://ncbi.nlm.nih.gov/pubmed/28445927 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29239 |
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