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8-Oxo-7,8-dihydroguanine in the Context of a Gene Promoter G-Quadruplex Is an On–Off Switch for Transcription
[Image: see text] Interplay between DNA repair of the oxidatively modified base 8-oxo-7,8-dihydroguanine (OG) and transcriptional activation has been documented in mammalian genes. Previously, we synthesized OG into the VEGF potential G-quadruplex sequence (PQS) in the coding strand of a luciferase...
Shranjeno v:
| izdano v: | ACS Chem Biol |
|---|---|
| Main Authors: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical
Society
2017
|
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5604463/ https://ncbi.nlm.nih.gov/pubmed/28829124 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.7b00636 |
| Oznake: |
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