Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

Cancer cells alter their metabolism for the production of precursors of macromolecules. However, the control mechanisms underlying this reprogramming are poorly understood. Here we show that metabolic reprogramming of colorectal cancer is caused chiefly by aberrant MYC expression. Multiomics-based a...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Satoh, Kiyotoshi, Yachida, Shinichi, Sugimoto, Masahiro, Oshima, Minoru, Nakagawa, Toshitaka, Akamoto, Shintaro, Tabata, Sho, Saitoh, Kaori, Kato, Keiko, Sato, Saya, Igarashi, Kaori, Aizawa, Yumi, Kajino-Sakamoto, Rie, Kojima, Yasushi, Fujishita, Teruaki, Enomoto, Ayame, Hirayama, Akiyoshi, Ishikawa, Takamasa, Taketo, Makoto Mark, Kushida, Yoshio, Haba, Reiji, Okano, Keiichi, Tomita, Masaru, Suzuki, Yasuyuki, Fukuda, Shinji, Aoki, Masahiro, Soga, Tomoyoshi
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
PNAS Plus
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604037/
https://ncbi.nlm.nih.gov/pubmed/28847964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710366114
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