Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC

Cancer cells alter their metabolism for the production of precursors of macromolecules. However, the control mechanisms underlying this reprogramming are poorly understood. Here we show that metabolic reprogramming of colorectal cancer is caused chiefly by aberrant MYC expression. Multiomics-based a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Satoh, Kiyotoshi, Yachida, Shinichi, Sugimoto, Masahiro, Oshima, Minoru, Nakagawa, Toshitaka, Akamoto, Shintaro, Tabata, Sho, Saitoh, Kaori, Kato, Keiko, Sato, Saya, Igarashi, Kaori, Aizawa, Yumi, Kajino-Sakamoto, Rie, Kojima, Yasushi, Fujishita, Teruaki, Enomoto, Ayame, Hirayama, Akiyoshi, Ishikawa, Takamasa, Taketo, Makoto Mark, Kushida, Yoshio, Haba, Reiji, Okano, Keiichi, Tomita, Masaru, Suzuki, Yasuyuki, Fukuda, Shinji, Aoki, Masahiro, Soga, Tomoyoshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604037/
https://ncbi.nlm.nih.gov/pubmed/28847964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1710366114
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