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5-hydroxymethylcytosine accumulation in postmitotic neurons results in functional demethylation of expressed genes

5-hydroxymethylcytosine (5hmC) occurs at maximal levels in postmitotic neurons, where its accumulation is cell-specific and correlated with gene expression. Here we demonstrate that the distribution of 5hmC in CG and non-CG dinucleotides is distinct and that it reflects the binding specificity and g...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Proc Natl Acad Sci U S A
मुख्य लेखकों: Mellén, Marian, Ayata, Pinar, Heintz, Nathaniel
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: National Academy of Sciences 2017
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC5604027/
https://ncbi.nlm.nih.gov/pubmed/28847947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1708044114
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