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Study of the Role of siRNA Mediated Promoter Methylation in DNMT3B Knockdown and Alteration of Promoter Methylation of CDH1, GSTP1 Genes in MDA-MB -453 Cell Line

Promoter methylation is one of the main epigenetic mechanisms that leads to the inactivation of tumor suppressor genes during carcinogenesis. Due to the reversible nature of DNA methylation, many studies have been performed to correct theses epigenetic defects by inhibiting DNA methyltransferases (D...

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Publicado en:Iran J Pharm Res
Main Authors: Naghitorabi, Mojgan, Mir Mohammad Sadeghi, Hamid, Mohammadi Asl, Javad, Rabbani, Mohammad, Jafarian-Dehkordi, Abbas
Formato: Artigo
Idioma:Inglês
Publicado: Shaheed Beheshti University of Medical Sciences 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603887/
https://ncbi.nlm.nih.gov/pubmed/28979331
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