Illustrating, Quantifying, and Correcting for Bias in Post-hoc Analysis of Gene-Based Rare Variant Tests of Association

To date, gene-based rare variant testing approaches have focused on aggregating information across sets of variants to maximize statistical power in identifying genes showing significant association with diseases. Beyond identifying genes that are associated with diseases, the identification of caus...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Grinde, Kelsey E., Arbet, Jaron, Green, Alden, O'Connell, Michael, Valcarcel, Alessandra, Westra, Jason, Tintle, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603735/
https://ncbi.nlm.nih.gov/pubmed/28959274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2017.00117
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