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Evaluating the impact of genotype errors on rare variant tests of association

The new class of rare variant tests has usually been evaluated assuming perfect genotype information. In reality, rare variant genotypes may be incorrect, and so rare variant tests should be robust to imperfect data. Errors and uncertainty in SNP genotyping are already known to dramatically impact s...

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Detalhes bibliográficos
Main Authors: Cook, Kaitlyn, Benitez, Alejandra, Fu, Casey, Tintle, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3978329/
https://ncbi.nlm.nih.gov/pubmed/24744770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00062
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