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Assessing the Impact of Non-Differential Genotyping Errors on Rare Variant Tests of Association

BACKGROUND/AIMS: We aim to quantify the effect of non-differential genotyping errors on the power of rare variant tests and identify those situations when genotyping errors are most harmful. METHODS: We simulated genotype and phenotype data for a range of sample sizes, minor allele frequencies, dise...

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Detalhes bibliográficos
Main Authors: Powers, Scott, Gopalakrishnan, Shyam, Tintle, Nathan
Formato: Artigo
Idioma:Inglês
Publicado em: S. Karger AG 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3214826/
https://ncbi.nlm.nih.gov/pubmed/22004945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000332222
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