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Constraints and consequences of the emergence of amino acid repeats in eukaryotic proteins

Proteins with amino acid homorepeats have the potential to be detrimental to cells and are often associated with human diseases. Why then are homorepeats prevalent in eukaryotic proteomes? In yeast, we find that homorepeats are enriched in proteins that are essential, pleiotropic and buffer environm...

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Bibliografiske detaljer
Udgivet i:Nat Struct Mol Biol
Main Authors: Chavali, Sreenivas, Chavali, Pavithra L., Chalancon, Guilhem, Sanchez de Groot, Natalia, Gemayel, Rita, Latysheva, Natasha S., Ing-Simmons, Elizabeth, Verstrepen, Kevin J., Balaji, Santhanam, Babu, M. Madan
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603276/
https://ncbi.nlm.nih.gov/pubmed/28805808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3441
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