Candidate gene analysis for Alzheimer’s disease in adults with Down syndrome

Individuals with Down syndrome (DS) overexpress many genes on chromosome 21 due to trisomy and have high risk of dementia due to the Alzheimer’s disease (AD) neuropathology. However, there is a wide range of phenotypic differences (e.g., age at onset of AD, amyloid β levels) among adults with DS, su...

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Veröffentlicht in:Neurobiol Aging
Hauptverfasser: Lee, Joseph H., Lee, Annie J., Dang, Lam-Ha, Pang, Deborah, Kisselev, Sergey, Krinsky-McHale, Sharon J., Zigman, Warren B., Luchsinger, José A., Silverman, Wayne, Tycko, Benjamin, Clark, Lorraine N., Schupf, Nicole
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603247/
https://ncbi.nlm.nih.gov/pubmed/28554490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neurobiolaging.2017.04.018
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