Polyethylenimine Nanoparticle-Mediated siRNA Delivery to Reduce α-Synuclein Expression in a Model of Parkinson’s Disease

RNA interference (RNAi)-based strategies that mediate the specific knockdown of target genes by administration of small interfering RNAs (siRNAs) could be applied for treatment of presently incurable neurodegenerative diseases such as Parkinson’s disease. However, inefficient delivery of siRNA into...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Helmschrodt, Christin, Höbel, Sabrina, Schöniger, Sandra, Bauer, Anne, Bonicelli, Jana, Gringmuth, Marieke, Fietz, Simone A., Aigner, Achim, Richter, Angelika, Richter, Franziska
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602522/
https://ncbi.nlm.nih.gov/pubmed/29246324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.08.013
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