Intermolecular interactions involving an acidic patch on immunoglobulin variable domain and the γ2 constant region mediate crystalline inclusion body formation in the endoplasmic reticulum

Full-length immunoglobulins (Igs) are widely considered difficult to crystallize because of their large size, N-linked glycosylation, and flexible hinge region. However, numerous cases of intracellular Ig crystallization are reported in plasma cell dyscrasias. What makes some Ig clones more prone to...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:Cell Logist
Huvudupphovsmän: Hasegawa, Haruki, Geng, Mei, Ketchem, Randal R., Liu, Ling, Graham, Kevin, Jacobsen, Frederick
Materialtyp: Artigo
Språk:Inglês
Publicerad: Taylor & Francis 2017
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5602423/
https://ncbi.nlm.nih.gov/pubmed/28944095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21592799.2017.1361499
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk