An HDAC3-PROX1 corepressor module acts on HNF4α to control hepatic triglycerides

The histone deacetylase HDAC3 is a critical mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver. To elucidate the underlying mechanism, here we report a method of cross-linking followed by mass spectrometry to define a high-confidence HDAC3 interactome in...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Armour, Sean M., Remsberg, Jarrett R., Damle, Manashree, Sidoli, Simone, Ho, Wesley Y., Li, Zhenghui, Garcia, Benjamin A., Lazar, Mitchell A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601916/
https://ncbi.nlm.nih.gov/pubmed/28916805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00772-5
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker