Deletion of histone deacetylase 3 in adult beta cells improves glucose tolerance via increased insulin secretion

OBJECTIVE: Histone deacetylases are epigenetic regulators known to control gene transcription in various tissues. A member of this family, histone deacetylase 3 (HDAC3), has been shown to regulate metabolic genes. Cell culture studies with HDAC-specific inhibitors and siRNA suggest that HDAC3 plays...

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Detalhes bibliográficos
Publicado no:Mol Metab
Main Authors: Remsberg, Jarrett R., Ediger, Benjamin N., Ho, Wesley Y., Damle, Manashree, Li, Zhenghui, Teng, Christopher, Lanzillotta, Cristina, Stoffers, Doris A., Lazar, Mitchell A.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5220396/
https://ncbi.nlm.nih.gov/pubmed/28123935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2016.11.007
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