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6-bromo-indirubin-3′-oxime (6BIO), a Glycogen synthase kinase-3β inhibitor, activates cytoprotective cellular modules and suppresses cellular senescence-mediated biomolecular damage in human fibroblasts

As genetic interventions or extended caloric restriction cannot be applied in humans, many studies have been devoted to the identification of natural products that can prolong healthspan. 6-bromoindirubin-3′-oxime (6BIO), a hemi-synthetic derivative of indirubins found in edible mollusks and plants,...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Sklirou, Aimilia D., Gaboriaud-Kolar, Nicolas, Papassideri, Issidora, Skaltsounis, Alexios-Leandros, Trougakos, Ioannis P.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601901/
https://ncbi.nlm.nih.gov/pubmed/28916781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11662-7
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