High PHLPP1 expression levels predicts longer time of acquired resistance to EGFR tyrosine kinase inhibitors in patients with lung adenocarcinoma

BACKGROUND: In spite of an initial good response to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR TKIs) in lung adenocarcinoma patients, resistance to treatment eventually occurs. Epidermal growth factor receptor (EGFR) activation stimulates Ras/Raf/Erk/MAPK and influences PI3K/A...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xie, Youyou, Lv, Dongqing, Wang, Wei, Ye, Minhua, Chen, Xiaofeng, Yang, Haihua
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601709/
https://ncbi.nlm.nih.gov/pubmed/28938613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19777
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