The mechanism of acquired resistance to irreversible EGFR tyrosine kinase inhibitor-afatinib in lung adenocarcinoma patients

INTRODUCTION: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are associated with favorable response in EGFR mutant lung cancer. Acquired resistance to reversible EGFR TKIs remains a significant barrier, and acquired EGFR T790M-mutation is the major mechanism. Second-genera...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wu, Shang-Gin, Liu, Yi-Nan, Tsai, Meng-Feng, Chang, Yih-Leong, Yu, Chong-Jen, Yang, Pan-Chyr, Yang, James Chih-Hsin, Wen, Yueh-Feng, Shih, Jin-Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4914294/
https://ncbi.nlm.nih.gov/pubmed/26862733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7189
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