Anchimerically Activatable Antiviral ProTides

[Image: see text] This work describes the synthesis and biological evaluation of an anchimerically activated proTide of 2′-C-β-methylguanosine as an inhibitor of dengue virus 2 (DENV-2). The proTide incorporates a chemically cleavable 2-(methylthio)ethyl moiety and a HINT1 hydrolyzable tryptamine ph...

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Publicat a:ACS Med Chem Lett
Autors principals: Okon, Aniekan, Matos de Souza, Marcos Romário, Shah, Rachit, Amorim, Raquel, da Costa, Luciana Jesus, Wagner, Carston R.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2017
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601376/
https://ncbi.nlm.nih.gov/pubmed/28947944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00277
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