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Synthesis and Evaluation of Agelastatin Derivatives as Potent Modulators for Cancer Invasion and Metastasis

The synthesis of new agelastatin alkaloid derivatives and their anticancer evaluation in the context of the breast cancer microenvironment is described. A variety of N1-alkyl and C5-ether agelastatin derivatives were accessed via application of our strategy for convergent imidazolone synthesis from...

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Vydáno v:J Org Chem
Hlavní autoři: Antropow, Alyssa H., Xu, Kun, Buchsbaum, Rachel J., Movassaghi, Mohammad
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600481/
https://ncbi.nlm.nih.gov/pubmed/28696693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b01162
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