SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway

BACKGROUND: Estrone (E1), the major circulating estrogen in postmenopausal women, promotes estrogen-receptor positive (ER+) breast tumor growth and proliferation. Two major reactions contribute to E1 plasma concentrations, aromatase (CYP19A1) catalyzed E1 synthesis from androstenedione and steroid s...

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Published in:Breast Cancer Res Treat
Main Authors: Dudenkov, Tanda M., Ingle, James N., Buzdar, Aman U., Robson, Mark E., Kubo, Michiaki, Ibrahim-zada, Irada, Batzler, Anthony, Jenkins, Gregory D., Pietrzak, Tracy L., Carlson, Erin E., Barman, Poulami, Goetz, Matthew P., Northfelt, Donald W., Moreno-Aspita, Alvaro, Williard, Clark V., Kalari, Krishna R., Nakamura, Yusuke, Wang, Liewei, Weinshilboum, Richard M.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600471/
https://ncbi.nlm.nih.gov/pubmed/28429243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-017-4243-3
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